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Improved Production of Lipids in Oleaginous Yeast

Synthetic Biology
Lipids have a many applications, such as in foods, cosmetics & fuels. Oleaginous yeasts can produce high amounts of lipids and can be engineered using synbio. Here, we propose the development of novel methods to produce lipids at increased capacity.
Rodrigo Ledesma-Amaro
Rodrigo Ledesma-Amaro
GB
Funding requested
$249,000
Preclinical

Antibodies for Non-small-cell Lung Cancer

Oncology
We seek to de-risk humanized anti-TIGIT antibodies through in vivo studies with Biocytogen’s transgenic mouse lines. It would be of tremendous interest to further de-risk these antibodies to unlock their values.
Eric Goetz
Eric Goetz
US
Funding requested
$1,000,000
Preclinical

Discovery of Drugs for diabetic complications

Endocrinology
Rapid effect Low recurrence rate Non toxicity
KT
ken takabashi
JP
Funding requested
$900,000
Preclinical

Universal Coronavirus mRNA Vaccine (UCV-mRNA)

Infectious Disease/Vaccines
A functionally biosimilar mRNA prophylactic or therapeutic vaccine, or vaccine booster, to enable sustained immunity to current and future SARS-CoV-2 variants.
PA
Peter A. Jensen
IE
Funding requested
$500,000
Research

GenEX, Developing excipients for Gene Therapy

Liver Disease
Therapeutic viral vectors are common tools for gene delivery in research and clinical cell and gene therapy applications. These vectors have been widely used due to their efficiency in invading cells and introducing their genetic material. LUXTURNA (from Spark Therapeutics, Inc.)…
DS
Dr.Elham Shirvani-Dastgerdi
US
Funding requested
$ -
Research

Effect of different food types on cognitive ability

Neuroscience/Neurology
"You are what you eat" - food affects cognitive abilities of different social circles, potentially having major effect on or triggering conflicts between countries, classes and indigenous versus immigrant people. The research is going to verify effect by continuous testing of bas…
RE

US
Funding requested
$ -
Research

Creating IP Law system to protect LifeScienceData

Infectious Disease/Vaccines
Ageing
In order to properly protect LifeScienceData in the IP legal sense, we are exploring an appropriate new IP legal system which should harmonize IP system for the globe and existing IP legal system.
RE

JP
Funding requested
$ -
Research

Pan-betacoronavirus Neutralizing Antibodies

Immunology
Through Cure-Hub's independent COVID-19 antibody survey, I collected a few hundred serum samples. These were tested for neutralizing antibodies against the SARS-CoV-2 receptor binding domain (RBD). The RBD is important because it is responsible for viral binding to human cells, a…
Ian Martiszus
Ian Martiszus
US
Funding requested
$15,000
Research

Discovering a novel, alternative psilocybin production pathway

Mental Health
Inflammation
Neuroscience/Neurology
Regenerative medicine
Ageing
We have discovered that certain species of fungi produce psilocybin without having any gene homology with the genes that are known to be necessary and sufficient for psilocybin production. This indicates an undiscovered, non-canonical pathway for psilocybin production that we int…
NA
Nick Ainslie
US
Funding requested
$1,250,000
Early Stage

Discovering Novel Autophagy Activators

Ageing
Ageing is associated with the decline in the capacity of the autophagy pathway to degrade dysfunctional and damaging cellular components, such as protein aggregates and mitochondria. Dysfunctional autophagy, in turn, undermines other cellular functions including DNA repair, metab…
Viktor Korolchuk
Viktor Korolchuk
GB
Funding requested
$135,000
Preclinical

The Longevity Molecule

Ageing
Mental Health
Respiratory
The global elderly population is projected to substantially increase throughout the 21st century. By the year 2100 a fifth of the total world population will be aged 65 or older posing a serious socioeconomic challenge to societies world-wide.
Daniela Bakula
Daniela Bakula
DK
Funding requested
$500,000
Preclinical

Novel Anti-Metastatic Agents that Reverse Epithelial-Mesenchymal Transition in Cancer

Oncology
Dr. Daniel LaBarbera, with a team at the University of Colorado, has identified that TCF-transcription functions as a master regulator of EMT, and has discovered a novel factor within the TCF-transcription complex, CDH1L, as an inhibitor target, reversing EMT in CRC both in vitro…
Prof. Daniel LaBerbera
Prof. Daniel LaBerbera
US
Funding requested
$ -
Preclinical

Novel Antibody-Oligonucleotide Conjugates and Acquisition Method

Ageing
Researchers at the University of Hawai‘i John A. Burns School of Medicine have developed novel antibody-oligonucleotide conjugates (AOCs) and a method for acquiring them. Incorporating activated esters (e.g., N-hydroxysuccinimidyl esters) into DNA or RNA aptamer libraries enables…
RE

US
Funding requested
$ -
Preclinical

LIPO-V inhibits Radiation Induced Gastrointestinal Syndrome (RIGS)

Gastroenterology
Novel pharmaceutical composition (LIPO-V) is a modulator of WNT signaling induces for repair and regeneration of intestinal epithelium. LIPO-V protects/mitigates RIGS following acute gastrointestinal (GI) radiation exposure.
Prof. Subhrajit Saha
Prof. Subhrajit Saha
US
Funding requested
$ -
Preclinical

HMGA-1 Inhibitors

Gastroenterology
Oncology
Dr. Kennedy has developed a novel class of HMGA-1 inhibitors that can be used potentially in combination with existing chemotherapy agents for certain types of cancer.
Prof. Michael Kennedy
Prof. Michael Kennedy
US
Funding requested
$ -
Preclinical

High-Capacity Molecular Nanocapsules for Drug Delivery

Ageing
Inventors at the University of Missouri have developed stable metal-seamed nanocapsules with unprecedented stoichiometry, shape, and size, such that the internal volume is large and is completely isolated from the exterior of the capsule.
Prof. Jerry Atwood
Prof. Jerry Atwood
US
Funding requested
$ -
Preclinical

Type II Gonadotropin-Releasing Hormone Receptor and Gonadotropin-Releasing Hormone - III from Lamprey

Endocrinology
Inventors at the University of New Hampshire have cloned GnRH-III and a type II GnRH Receptor from lamprey (an eel-like fish model organism).Lamprey GnRH-III stimulates release of FSH, but not LH, which makes it a useful tool for studying and developing novel GnRH analogs that ca…
Prof. Stacia Sower
Prof. Stacia Sower
US
Funding requested
$ -
Preclinical

RNF167 and CASTOR1 as Novel mTOR Targets

Oncology
AKT-mediated phosphorylation of CASTOR1 significantly increases its binding to RNF167, revealing a novel mTORC1 regulating mechanism and potential new therapeutic targets for mTORC1-dysregulated diseases.
Prof. Shou-Jiang Gao
Prof. Shou-Jiang Gao
US
Funding requested
$ -
Preclinical

Small-Molecule Inhibitors of Nucleotide Excision Repair

Respiratory
Oncology
Here we report series of small-molecule inhibitors of interactions between XPA and ERCC1 identified by high-throughput screening (HTS) of compound libraries.
Prof. Dmitri Ivanov
Prof. Dmitri Ivanov
US
Funding requested
$ -
Preclinical

CAR T Preventive/Therapeutic Approach for Type 1 Diabetes

Immunology
Inflammation
Metabolism
Researchers at the University of Toledo have developed pancreatic beta-cell-specific chimeric antigen receptor (CAR) Tregs.
Prof. Juan Jaume
Prof. Juan Jaume
US
Funding requested
$ -
Preclinical

Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics

Oncology
The inventors have designed and synthesized a novel inhibitor consisting of a glycopolymer of 12 repeating units bearing a pendant saccharide unit that allows this inhibitor to bind heparanase tighter than previously utilized agents.
Prof. Hien Nguyen
Prof. Hien Nguyen
US
Funding requested
$ -
Clinical Trials

Minicircle Gene Therapy Against HIV

Immunology
Inflammation
Reproduction
Minicircle provides robust long-term, reversible expression of in vivo biologics without altering your preexisting genome. Minicircle is safe, ethical, accessible, and reversible gene therapy that can eradicate disease, reverse aging and transform public health.
WP
Walter Patterson
US
Funding requested
$3,999,996
Clinical Trials

Senasce: A Saliva Test for Measuring Biological Age

Ageing
At Biotein, we’re increasing the accessibility of proactive diagnostics for cellular health related to aging, using a lateral flow assay. It uses similar technology to pregnancy tests, costs 10-13% of current solutions, and detects proteins involved with almost all of the hallmar…
Nina Khera
Nina Khera
US
Funding requested
$ -
Early Stage

Non-toxic Cancer Drug Discovery Platform

Oncology
We have generated a unique database of human stem cell data and compare against cancer cells. Our platform identifies targets, e.g. for glioblastoma, confirming negligible expression in stem cells. We designed antisense oligonucleotides (ASOs) against these targets. All 6 drug ta…
RE

US
Funding requested
$3,354,000
Early Stage

IntraClear Biologics OU

Ageing
Age-related diseases are in the top of 10 leading causes of global deaths killing 110K people daily. One of the main causes of such diseases like atherosclerosis, Parkinson's disease, Alzheimer's disease, neuromuscular, inflammatory and other age-related pathologies is intracellu…
IM
Ilia Manzunin
US
Funding requested
$250,000
Clinical Trials

NEURO-iNN

Ageing
Neuroscience/Neurology
The company intend to invest in a new pharmacological per-os treatment based on proprietary, patented glutathione derivative and polyphenols from Olea europaea. This pharmaceutical formulation is supported by a robust pre-clinical rationale and by preliminary clinical evidence of…
AB
Andrea Bigozzi
US
Funding requested
$ -
Early Stage

Towards safe cellular rejuvenation

Ageing
Cell reprogramming offers a path to comprehensive rejuvenation but has a goldilocks problem. Too little and you have no rejuvenation, too much and you risk cancer. To fulfil its potential (comprehensive reversal of biological age, avoidance/mitigation of age linked disease), cell…
Daniel Ives
Daniel Ives
US
Funding requested
$ -
Preclinical

Small Molecule Replacements for Transcription Factors

Ageing
Oncology
We will leverage ML to design replacements for transcription factors implicated in longevity and cellular reprogramming. Numerous genes and transcription factors have been identified by other groups that can be used for cellular reprogramming or longevity extension (e.g. Yamanaka…
BO
Brennan Overhoff
US
Funding requested
$ -
Preclinical

Data Driven Anti-Ageing Drug Discovery and Repurposing

Ageing
The primary aim of this proposal is a proof-of-concept experiment to mimic one of the most impressive genetic lifespan synergies in a model organism using human prescription drugs for which transcriptional signatures are available. The ultimate aim is to develop a more general te…
Prof. Jan Gruber
Prof. Jan Gruber
SG
Funding requested
$151,900
Early Stage

Brain Cell Replacement Therapy

Ageing
Neuroscience/Neurology
Cardiology/Cardiovascular
A big challenge facing tissue and organ replacement as a strategy to beat aging relates to the brain. The brain, especially the neocortex - the part that underlies our highest cognitive functions and self-identity - cannot obviously be replaced as a whole organ. The neocortex can…
Dr. Jean Hebert
Dr. Jean Hebert
US
Funding requested
$250,000
Early Stage

A.I. for small molecule generation for any target protein

Ageing
First step of the A.I. for small molecule generation is to collect dataset that have SMILES of existing ligands. In order to train the model we should know proper protein structure to which small molecule binds. Then define its pocket 3D structure. This information is going to be…
Dauken Seitkali
Dauken Seitkali
KZ
Funding requested
$ -
Preclinical

Autoimmune Disease Treatment Without Immune Suppression

Gastroenterology
Bone/Joint/Connective Tissue
Immunology
Current drug regimes treat autoimmune diseases by suppressing the immune system with immunosuppressant drugs. However, this exposes patients to serious health risks: suppressing the immune system to treat autoimmune diseases leaves patients vulnerable to infections, which can be …
James Patrick Mixon PhD
James Patrick Mixon PhD
GB
Funding requested
$5,000,000
Preclinical

Lactocore: Innovative peptide-based approach to treat stress-related disorders

Mental Health
Lactocore is an innovative start-up, developing novel drugs based on milk-derived peptides. The current pipeline consists of a number of preclinical and research compounds. The most advanced drug, LCGA-17, has shown very high efficacy in animal models of anxiety, depression, and …
RE

US
Funding requested
$500,000
Clinical Trials

Novel antiseptic formulation for the treatment of blepharitis

Ophthalmology
Veloce BioPharma is clinical stage company that has successfully completed multiple phase 2 clinical trials in dermatology for indications that include molluscum contagiosum, chemotherapy associated paronychia, and common warts with our novel antiseptic formulation. As company fo…
Jesse  Pelletier MD FACS
Jesse Pelletier MD FACS
US
Funding requested
$5,000,000
Early Stage

Discovery of novel mitophagy activators for Alzheimer´s disease

Ageing
Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration. Failure to clear cellular damaged mitochondria is majorly caused by compromised mitophagy. Turning up mitophagy via pharmaceutical approaches could improve brain health, healthspan, and…
Evandro F. Fang
Evandro F. Fang
NO
Funding requested
$235,380
Early Stage

Exosomes for treating systemic inflammation

Ageing
Immunology
Inflammation
Chronic inflammation increases with age and contributes to several age-related diseases. Current anti-inflammatory treatments have unintended side-effects ranging from slight discomfort to life-threatening ailments. We have developed a novel anti-inflammatory therapeutic approach…
Gadi Turgeman
Gadi Turgeman
IL
Funding requested
$275,000
Early Stage

Probing DNA Quadruplexes in Age Related Proteostasis

Ageing
Our research will aim to establish the role of DNA Helicases (WRN and BLM) as positive regulators of proteostasis and understand their impact of declining function prior to the onset of age-related proteostasis. Furthermore, the project will aim to develop genetic and pharmacolog…
John Labbadia
John Labbadia
GB
Funding requested
$50,000
Preclinical

Screening for antibodies that modulate the risk for Alzheimer’s disease

Ageing
Neuroscience/Neurology
We screen blood and saliva of elderly (90+) nondemented individuals to identify antibodies that protected them from developing Alzheimer’s disease. The data generated will be used (i) for predicting Alzheimer’s disease risk in individuals (ii) for new Alzheimer’s disease therapeu…
Daniel Z. Bar
Daniel Z. Bar
IL
Funding requested
$250,000
Early Stage

Cellular ‘Soap’ For Infectious Disease Accelerated Aging

Ageing
Infectious Disease/Vaccines
Prevention of communicable disease via hygiene, antibiotics, vaccines, amongst other innovations has provided the largest life expectancy gains in human history. It is increasingly appreciated that pathogens age humans by driving their cell senescence. Our team has identified che…
Tim R. Peterson
Tim R. Peterson
US
Funding requested
$231,000
Early Stage

ApoptoSENS - Senolytic CAR-NK cells

Ageing
Over time, a subset of cells in our body experience damage and enter a state of senescence. Cellular senescence is the irreversible arrest of proliferation accompanied by proinflammatory factors that lead to tissue dysfunction. Selective elimination of these senescent cells has b…
Amit Sharma
Amit Sharma
US
Funding requested
$430,000
Preclinical

Towards reversing periodontal disease using Geroscience

Ageing
Oral Health
Periodontal disease (periodontitis) is a chronic oral disease impacting over 70% of older adults, where inflammation of the tissues supporting the teeth results in loss of connective tissue attachment, bone, and ultimately the tooth. The greatest underlying risk factor for period…
Jonathan An
Jonathan An
US
Funding requested
$330,000