IntraClear Biologics OU
Age-related diseases are in the top of 10 leading causes of global deaths killing 110K people daily. One of the main causes of such diseases like atherosclerosis, Parkinson's disease, Alzheimer's disease, neuromuscular, inflammatory and other age-related pathologies is intracellular junk (toxic compounds which cannot be destroyed by human organism itself, accumulated in most body tissues over time and lead to the development of serious pathologies). Modern medical approaches to age-related diseases are not particularly effective in perspective and are aimed at eliminating symptoms, not causes. We will create a therapy aimed at clearing the accumulation of the main types of intracellular junk to reduce the risk of developing cardiovascular, neurodegenerative, oncological and other pathologies, and significantly improve human healthspan.
Project Team
Project Status
Funding Opportunity
Background
Intracellular junk (lipofuscin, 7-ketocholesterol, etc) – one of the main causes of atherosclerosis, neurodegenerative (Parkinson's disease, Alzheimer's disease), neuromuscular, inflammatory and other age-related pathologies. Human physiological mechanisms, which is responsible for the recognition and degradation of intracellular junk, unable to cleave lipofuscin and 7-ketocholesterol. Such compounds are accumulated in most body tissues over time and lead to the development of serious pathologies. At this time there are still no developed universal approaches to creating therapies that can eliminate intracellular junk.
Project Details
Problem: modern medicine's approaches to age-related diseases are not particularly effective in perspective and are aimed at eliminating symptoms, not causes Solution: create a therapy aimed at clearing the accumulation of the main types of intracellular junk which cannot be cleaved by organism itself We will create a therapy aimed at clearing the accumulation of the main types of intracellular junk to reduce the risk of developing cardiovascular, neurodegenerative, oncological and other pathologies, and significantly improve human healthspan. We also develop a panel of primary ageing biomarkers. We are at the early stage. At the moment we are close to making a protocol for isolating lipofuscin from the tissue. We are also working on ageing biomarker based on lipofuscin. The project objectives also include a quantitative study of molecular and cellular damage, and the use of the data to create a panel of biomarkers that allows to objectively assess the biological age of a person. Range of applications: ● Reducing the risk of developing cardiovascular, neurodegenerative, oncological pathologies ● Improving the patient's condition in the presence of these pathologies ● Improving the quality of life — well-being and activity in people over 50 ● Cosmetic therapy — improvement of skin colour, structure and elasticity ● Optimization of other types of rejuvenation therapies ● Rejuvenation therapy — a set of procedures provided in a clinic ● Contract delivery to clinics of injectable solutions containing temporary gene therapy (allowing the production of enzymes directly inside the cells), or ready-made enzymes that clear intracellular junk ● In the course of work on the therapy, an express test will be created to determine the level of lipofuscin, which reflects the actual biological age and allows to estimate the number of enzymes necessary for the treatment of a particular person ● Skin cosmetology — plasters with microneedles, which contain enzymes that destroy lipofuscin
Project Timeline
Current project status
Required FundingN/A
Statusongoing
Duration6 MonthsA histological and cytological analysis of tissues of various organs is carried out with the study of lipofuscin accumulation, as well as histological and cytological analysis of atherosclerotic plaques in people of different age groups
Preclinical
Required Funding$125,000
Statusplanned
Duration24 MonthsHistological and cytological examination of skin tissues, muscles, brain, liver, etc. Identification of lipofuscin granules in them, visual comparison, studying lipofuscin accumulation in different tissues (create basis for the next project stages - enzyme search and therapy development)
Preclinical
Required Funding$125,000
Statusplanned
Duration24 MonthsPublish the histological atlas (virtual / physical) of lipofuscin content in different tissues in people of different ages / sex / with different pathologies Create the basis for technology for the isolation of lipofuscin from tissues, preparation for patenting