Clinically relevant genotypes & phenotypes of PCOS
Investigate clinically important genotypes and phenotypes of PCOS with distinct differences observed in women of different ethnicities. Using a big data approach in a multi-ethnic cohort to unravel the complex molecular mechanisms governing PCOS.
Project Team
Project Status
Funding Opportunity
Background
This group has extensive experience in women’s health research, spanning across in vitro models in the laboratory to pre-clinical mouse models to translational human clinical studies. Their mission is dedicated to understanding and improving women’s reproductive outcomes and healthspan to change the narrative of female reproductive longevity.
Project Details
In this project, they propose a unique multi-pronged approach to study PCOS, a multi-factorial disease. This is the first study to integrate various platforms to obtain a clearer understanding of PCOS in an effort to develop better diagnostic biomarkers and potential medical interventions targeted at managing both reproductive problems as well as potential health complications associated in women with PCOS such as diabetes mellitus and endometrial cancer.
Project Timeline
Primary Data Collection
Required Funding$250,000
Statusplanned
Duration12 MonthsA new and innovative project aimed directly at investigating the clinically important genotypes and phenotypes of polycystic ovarian syndrome (PCOS), which afflicts 4-20% of all women at reproductive age, with distinct differences observed in women of different ethnicities. Women suffering from PCOS experience amenorrhea, ovarian cysts, hyperandrogenism and hirsutism with potential health implications in later life. The exact etiology of PCOS is elusive and currently remains without a cure. Using an integrated big data approach in a unique multi-ethnic cohort, we aim to unravel the complex molecular mechanisms governing PCOS.