Reproglia to seek $200k for stem cell molecule

Ageing
Inflammation
Metabolism
Neuroscience/Neurology
Regenerative medicine

Age-related diseases pose a pressing global health challenge, affecting a significant and growing portion of the population. The urgency to find effective solutions is paramount, given the current and projected future impact on individuals worldwide.

Project Team

Kun-Hyung Roh
Kun-Hyung Roh

Institutions

Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
US
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
US
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
US
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
US
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
US

Project Status

Clinical Stage
Preclinical
Patent Status
Patent not filed

Funding Opportunity

Opportunity type
Funding requested
$199,999
Funding allocated
$0

Background

Our research group has been working on a cutting-edge approach to reverse aging using the renowned Yamanaka Factors, and we need support to take it to the next level. Recent breakthrough research by Sinclair and his colleagues at Harvard has demonstrated that the transgenic expression of three specific Yamanaka Factors in retinal cells can reprogram them into a youthful state without tumor growth. This means that we can reverse the aging process in cells without any side effects by using these three factors. We have developed the world's first computer model that can predict which drugs can induce the expression of these factors in specific cell lines. Through our research, we have already identified several promising small molecules that show the potential to reverse age-related processes. Amazingly, some of these drugs are already FDA-approved, ensuring a faster path to market with reduced risks. In addition, small molecules are much safer when compared to potential side effects that may result from transgenic approaches in humans. We seek for funding in order to validate the predictions in real-life biological models under controlled settings. With a solid scientific foundation rooted in molecular-level understanding, we are confident in our ability to repurpose existing FDA-approved and experimental drugs at significantly lower costs compared to traditional drug discovery pipelines. Join us on this journey to bring the power of the Yamanaka Factors in a single pill. This is a unique investment opportunity for you to share the amazing results of small molecules that can extend human lifespan and reverse damages, revolutionizing the future of human longevity.

Project Details

Age-related diseases pose a pressing global health challenge, affecting a significant and growing portion of the population. The urgency to find effective solutions is paramount, given the current and projected future impact on individuals worldwide.

Project Timeline

  • Clinical Trials

    Required FundingN/A
    Statusplanned
    Duration24 Months

    -

  • Preclinical studies on C. elegans and human cells

    Required Funding$199,999
    Statusongoing
    Duration30 Months

    The identified drugs will be tested via our lab's high-throughput screening methods to assess their potential in reversing age-related processes in aging C. elegans, and specifically in an Alzheimer's Disease model. We will also perform lifespan studies in order to test lifespan extension. C. elegans is an excellent model organism that shares remarkable resembling features with humans, widely used in drug discovery and aging studies due to their short lifespan.

  • Preclinical studies on mouse models

    Required FundingN/A
    Statusplanned
    Duration20 Months

    -