Discover Research Projects

Make a new antiobiotic medicine for inflammation

Dr. Daniel LaBarbera, with a team at the University of Colorado, has identified that TCF-transcription functions as a master regulator of EMT, and has discovered a novel factor within the TCF-transcription complex, CDH1L, as an inhibitor target, reversing EMT in CRC both in vitro…

Researchers at the University of Hawai‘i John A. Burns School of Medicine have developed novel antibody-oligonucleotide conjugates (AOCs) and a method for acquiring them. Incorporating activated esters (e.g., N-hydroxysuccinimidyl esters) into DNA or RNA aptamer libraries enables…

Novel pharmaceutical composition (LIPO-V) is a modulator of WNT signaling induces for repair and regeneration of intestinal epithelium. LIPO-V protects/mitigates RIGS following acute gastrointestinal (GI) radiation exposure.

Dr. Kennedy has developed a novel class of HMGA-1 inhibitors that can be used potentially in combination with existing chemotherapy agents for certain types of cancer.

Inventors at the University of Missouri have developed stable metal-seamed nanocapsules with unprecedented stoichiometry, shape, and size, such that the internal volume is large and is completely isolated from the exterior of the capsule.

Inventors at the University of New Hampshire have cloned GnRH-III and a type II GnRH Receptor from lamprey (an eel-like fish model organism).Lamprey GnRH-III stimulates release of FSH, but not LH, which makes it a useful tool for studying and developing novel GnRH analogs that ca…

AKT-mediated phosphorylation of CASTOR1 significantly increases its binding to RNF167, revealing a novel mTORC1 regulating mechanism and potential new therapeutic targets for mTORC1-dysregulated diseases.

Here we report series of small-molecule inhibitors of interactions between XPA and ERCC1 identified by high-throughput screening (HTS) of compound libraries.

Researchers at the University of Toledo have developed pancreatic beta-cell-specific chimeric antigen receptor (CAR) Tregs.

The inventors have designed and synthesized a novel inhibitor consisting of a glycopolymer of 12 repeating units bearing a pendant saccharide unit that allows this inhibitor to bind heparanase tighter than previously utilized agents.

Minicircle provides robust long-term, reversible expression of in vivo biologics without altering your preexisting genome. Minicircle is safe, ethical, accessible, and reversible gene therapy that can eradicate disease, reverse aging and transform public health.

At Biotein, we’re increasing the accessibility of proactive diagnostics for cellular health related to aging, using a lateral flow assay. It uses similar technology to pregnancy tests, costs 10-13% of current solutions, and detects proteins involved with almost all of the hallmar…

We have generated a unique database of human stem cell data and compare against cancer cells. Our platform identifies targets, e.g. for glioblastoma, confirming negligible expression in stem cells. We designed antisense oligonucleotides (ASOs) against these targets. All 6 drug ta…

Age-related diseases are in the top of 10 leading causes of global deaths killing 110K people daily. One of the main causes of such diseases like atherosclerosis, Parkinson's disease, Alzheimer's disease, neuromuscular, inflammatory and other age-related pathologies is intracellu…

Saunas have multiple benefits. Sweating is the fastest way of removing salt from the body, therefore saunas are effective measures against high blood pressure due to salt. However, it is also believed that saunas invoke the heat shock response. The heat shock response is a genera…

The company intend to invest in a new pharmacological per-os treatment based on proprietary, patented glutathione derivative and polyphenols from Olea europaea. This pharmaceutical formulation is supported by a robust pre-clinical rationale and by preliminary clinical evidence of…

Cell reprogramming offers a path to comprehensive rejuvenation but has a goldilocks problem. Too little and you have no rejuvenation, too much and you risk cancer. To fulfil its potential (comprehensive reversal of biological age, avoidance/mitigation of age linked disease), cell…

We will leverage ML to design replacements for transcription factors implicated in longevity and cellular reprogramming. Numerous genes and transcription factors have been identified by other groups that can be used for cellular reprogramming or longevity extension (e.g. Yamanaka…

The primary aim of this proposal is a proof-of-concept experiment to mimic one of the most impressive genetic lifespan synergies in a model organism using human prescription drugs for which transcriptional signatures are available. The ultimate aim is to develop a more general te…

A big challenge facing tissue and organ replacement as a strategy to beat aging relates to the brain. The brain, especially the neocortex - the part that underlies our highest cognitive functions and self-identity - cannot obviously be replaced as a whole organ. The neocortex can…

Problem Patients are often confused for the help they need to set goals, motivate them to get healthy, follow the cycle to take medicines. There is lot of info online but do not help eachperson like a coach or role model.Our conversational AI solution built on AI, ML and NLP and …

First step of the A.I. for small molecule generation is to collect dataset that have SMILES of existing ligands. In order to train the model we should know proper protein structure to which small molecule binds. Then define its pocket 3D structure. This information is going to be…

Current drug regimes treat autoimmune diseases by suppressing the immune system with immunosuppressant drugs. However, this exposes patients to serious health risks: suppressing the immune system to treat autoimmune diseases leaves patients vulnerable to infections, which can be …

Lactocore is an innovative start-up, developing novel drugs based on milk-derived peptides. The current pipeline consists of a number of preclinical and research compounds. The most advanced drug, LCGA-17, has shown very high efficacy in animal models of anxiety, depression, and …

Veloce BioPharma is clinical stage company that has successfully completed multiple phase 2 clinical trials in dermatology for indications that include molluscum contagiosum, chemotherapy associated paronychia, and common warts with our novel antiseptic formulation. As company fo…

Chronic inflammation increases with age and contributes to several age-related diseases. Current anti-inflammatory treatments have unintended side-effects ranging from slight discomfort to life-threatening ailments. We have developed a novel anti-inflammatory therapeutic approach…

Our research will aim to establish the role of DNA Helicases (WRN and BLM) as positive regulators of proteostasis and understand their impact of declining function prior to the onset of age-related proteostasis. Furthermore, the project will aim to develop genetic and pharmacolog…

We screen blood and saliva of elderly (90+) nondemented individuals to identify antibodies that protected them from developing Alzheimer’s disease. The data generated will be used (i) for predicting Alzheimer’s disease risk in individuals (ii) for new Alzheimer’s disease therapeu…

Prevention of communicable disease via hygiene, antibiotics, vaccines, amongst other innovations has provided the largest life expectancy gains in human history. It is increasingly appreciated that pathogens age humans by driving their cell senescence. Our team has identified che…

Over time, a subset of cells in our body experience damage and enter a state of senescence. Cellular senescence is the irreversible arrest of proliferation accompanied by proinflammatory factors that lead to tissue dysfunction. Selective elimination of these senescent cells has b…

Periodontal disease (periodontitis) is a chronic oral disease impacting over 70% of older adults, where inflammation of the tissues supporting the teeth results in loss of connective tissue attachment, bone, and ultimately the tooth. The greatest underlying risk factor for period…