Discover Research Projects
Invest in biopharma researchers and their work
Recently funded projects
Successfully funded
Discovering Novel Autophagy Activators
Ageing is associated with the decline in the capacity of the autophagy pathway to degrade dysfunctional and damaging cellular components, such as protein aggregates and mitochondri…
$285,000
Funded by VitaDAO
Funded by VitaDAO
Successfully funded
The Longevity Molecule
The global elderly population is projected to substantially increase throughout the 21st century. By the year 2100 a fifth of the total world population will be aged 65 or older po…
$250,000
Funded by VitaDAO
Funded by VitaDAO
Successfully funded
Discovery of novel mitophagy activators for Alzheimer´s disease
Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration. Failure to clear cellular damaged mitochondria is majorly caused by compromised mitop…
$300,000
Funded by VitaDAO
Funded by VitaDAO
All research projects
Research
Antibiotics
Ageing
Make a new antiobiotic medicine for inflammation
RE
Funding requested
$ -
$ -
Preclinical
Novel Anti-Metastatic Agents that Reverse Epithelial-Mesenchymal Transition in Cancer
Oncology
Dr. Daniel LaBarbera, with a team at the University of Colorado, has identified that TCF-transcription functions as a master regulator of EMT, and has discovered a novel factor within the TCF-transcription complex, CDH1L, as an inhibitor target, reversing EMT in CRC both in vitro…
Prof. Daniel LaBerbera
Funding requested
$ -
$ -
Preclinical
Novel Antibody-Oligonucleotide Conjugates and Acquisition Method
Ageing
Researchers at the University of Hawai‘i John A. Burns School of Medicine have developed novel antibody-oligonucleotide conjugates (AOCs) and a method for acquiring them. Incorporating activated esters (e.g., N-hydroxysuccinimidyl esters) into DNA or RNA aptamer libraries enables…
RE
Funding requested
$ -
$ -
Preclinical
LIPO-V inhibits Radiation Induced Gastrointestinal Syndrome (RIGS)
Gastroenterology
Novel pharmaceutical composition (LIPO-V) is a modulator of WNT signaling induces for repair and regeneration of intestinal epithelium. LIPO-V protects/mitigates RIGS following acute gastrointestinal (GI) radiation exposure.
Prof. Subhrajit Saha
Funding requested
$ -
$ -
Preclinical
HMGA-1 Inhibitors
Gastroenterology
Oncology
Dr. Kennedy has developed a novel class of HMGA-1 inhibitors that can be used potentially in combination with existing chemotherapy agents for certain types of cancer.
Prof. Michael Kennedy
Funding requested
$ -
$ -
Preclinical
High-Capacity Molecular Nanocapsules for Drug Delivery
Ageing
Inventors at the University of Missouri have developed stable metal-seamed nanocapsules with unprecedented stoichiometry, shape, and size, such that the internal volume is large and is completely isolated from the exterior of the capsule.
Prof. Jerry Atwood
Funding requested
$ -
$ -
Preclinical
Type II Gonadotropin-Releasing Hormone Receptor and Gonadotropin-Releasing Hormone - III from Lamprey
Endocrinology
Inventors at the University of New Hampshire have cloned GnRH-III and a type II GnRH Receptor from lamprey (an eel-like fish model organism).Lamprey GnRH-III stimulates release of FSH, but not LH, which makes it a useful tool for studying and developing novel GnRH analogs that ca…
Prof. Stacia Sower
Funding requested
$ -
$ -
Preclinical
RNF167 and CASTOR1 as Novel mTOR Targets
Oncology
AKT-mediated phosphorylation of CASTOR1 significantly increases its binding to RNF167, revealing a novel mTORC1 regulating mechanism and potential new therapeutic targets for mTORC1-dysregulated diseases.
Prof. Shou-Jiang Gao
Funding requested
$ -
$ -
Preclinical
Small-Molecule Inhibitors of Nucleotide Excision Repair
Respiratory
Oncology
Here we report series of small-molecule inhibitors of interactions between XPA and ERCC1 identified by high-throughput screening (HTS) of compound libraries.
Prof. Dmitri Ivanov
Funding requested
$ -
$ -
Preclinical
CAR T Preventive/Therapeutic Approach for Type 1 Diabetes
Immunology
Inflammation
Metabolism
Researchers at the University of Toledo have developed pancreatic beta-cell-specific chimeric antigen receptor (CAR) Tregs.
Prof. Juan Jaume
Funding requested
$ -
$ -
Preclinical
Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics
Oncology
The inventors have designed and synthesized a novel inhibitor consisting of a glycopolymer of 12 repeating units bearing a pendant saccharide unit that allows this inhibitor to bind heparanase tighter than previously utilized agents.
Prof. Hien Nguyen
Funding requested
$ -
$ -
Clinical Trials
Minicircle Gene Therapy Against HIV
Immunology
Inflammation
Reproduction
Minicircle provides robust long-term, reversible expression of in vivo biologics without altering your preexisting genome. Minicircle is safe, ethical, accessible, and reversible gene therapy that can eradicate disease, reverse aging and transform public health.
Mac Davis
Funding requested
$3,999,996
$3,999,996
Clinical Trials
Senasce: A Saliva Test for Measuring Biological Age
Ageing
At Biotein, we’re increasing the accessibility of proactive diagnostics for cellular health related to aging, using a lateral flow assay. It uses similar technology to pregnancy tests, costs 10-13% of current solutions, and detects proteins involved with almost all of the hallmar…
Nina Khera
Funding requested
$ -
$ -
Early Stage
Non-toxic Cancer Drug Discovery Platform
Oncology
We have generated a unique database of human stem cell data and compare against cancer cells. Our platform identifies targets, e.g. for glioblastoma, confirming negligible expression in stem cells. We designed antisense oligonucleotides (ASOs) against these targets. All 6 drug ta…
RE
Funding requested
$3,354,000
$3,354,000
Early Stage
IntraClear Biologics OU
Ageing
Age-related diseases are in the top of 10 leading causes of global deaths killing 110K people daily. One of the main causes of such diseases like atherosclerosis, Parkinson's disease, Alzheimer's disease, neuromuscular, inflammatory and other age-related pathologies is intracellu…
Ariel Feinerman
Funding requested
$250,000
$250,000
Early Stage
Pragmatic Heat Shock Response Activation
Ageing
Saunas have multiple benefits. Sweating is the fastest way of removing salt from the body, therefore saunas are effective measures against high blood pressure due to salt. However, it is also believed that saunas invoke the heat shock response. The heat shock response is a genera…
Aaron King
Funding requested
$5,000
$5,000
Clinical Trials
NEURO-iNN
Ageing
Neuroscience/Neurology
The company intend to invest in a new pharmacological per-os treatment based on proprietary, patented glutathione derivative and polyphenols from Olea europaea. This pharmaceutical formulation is supported by a robust pre-clinical rationale and by preliminary clinical evidence of…
Olivero Giusti
Funding requested
$ -
$ -
Early Stage
Towards safe cellular rejuvenation
Ageing
Cell reprogramming offers a path to comprehensive rejuvenation but has a goldilocks problem. Too little and you have no rejuvenation, too much and you risk cancer. To fulfil its potential (comprehensive reversal of biological age, avoidance/mitigation of age linked disease), cell…
Daniel Ives
Funding requested
$ -
$ -
Preclinical
Small Molecule Replacements for Transcription Factors
Ageing
Oncology
We will leverage ML to design replacements for transcription factors implicated in longevity and cellular reprogramming. Numerous genes and transcription factors have been identified by other groups that can be used for cellular reprogramming or longevity extension (e.g. Yamanaka…
Ram Samudrala
Funding requested
$ -
$ -
Preclinical
Data Driven Anti-Ageing Drug Discovery and Repurposing
Ageing
The primary aim of this proposal is a proof-of-concept experiment to mimic one of the most impressive genetic lifespan synergies in a model organism using human prescription drugs for which transcriptional signatures are available. The ultimate aim is to develop a more general te…
Prof. Jan Gruber
Funding requested
$151,900
$151,900
Early Stage
Brain Cell Replacement Therapy
Ageing
Neuroscience/Neurology
Cardiology/Cardiovascular
A big challenge facing tissue and organ replacement as a strategy to beat aging relates to the brain. The brain, especially the neocortex - the part that underlies our highest cognitive functions and self-identity - cannot obviously be replaced as a whole organ. The neocortex can…
Dr. Jean Hebert
Funding requested
$250,000
$250,000
Early Stage
Therapeutics and wellness for Psoriasis, Neurofibromatosis
Mental Health
Immunology
Inflammation
Dermatology
Problem Patients are often confused for the help they need to set goals, motivate them to get healthy, follow the cycle to take medicines. There is lot of info online but do not help eachperson like a coach or role model.Our conversational AI solution built on AI, ML and NLP and …
RE
Funding requested
$ -
$ -
Early Stage
A.I. for small molecule generation for any target protein
Ageing
First step of the A.I. for small molecule generation is to collect dataset that have SMILES of existing ligands. In order to train the model we should know proper protein structure to which small molecule binds. Then define its pocket 3D structure. This information is going to be…
Dauken Seitkali
Funding requested
$ -
$ -
Preclinical
Autoimmune Disease Treatment Without Immune Suppression
Gastroenterology
Bone/Joint/Connective Tissue
Immunology
Current drug regimes treat autoimmune diseases by suppressing the immune system with immunosuppressant drugs. However, this exposes patients to serious health risks: suppressing the immune system to treat autoimmune diseases leaves patients vulnerable to infections, which can be …
James Patrick Mixon PhD
Funding requested
$5,000,000
$5,000,000
Preclinical
Lactocore: Innovative peptide-based approach to treat stress-related disorders
Mental Health
Lactocore is an innovative start-up, developing novel drugs based on milk-derived peptides. The current pipeline consists of a number of preclinical and research compounds. The most advanced drug, LCGA-17, has shown very high efficacy in animal models of anxiety, depression, and …
RE
Funding requested
$500,000
$500,000
Clinical Trials
Novel antiseptic formulation for the treatment of blepharitis
Ophthalmology
Veloce BioPharma is clinical stage company that has successfully completed multiple phase 2 clinical trials in dermatology for indications that include molluscum contagiosum, chemotherapy associated paronychia, and common warts with our novel antiseptic formulation. As company fo…
Jesse Pelletier MD FACS
Funding requested
$5,000,000
$5,000,000
Early Stage
Exosomes for treating systemic inflammation
Ageing
Immunology
Inflammation
Chronic inflammation increases with age and contributes to several age-related diseases. Current anti-inflammatory treatments have unintended side-effects ranging from slight discomfort to life-threatening ailments. We have developed a novel anti-inflammatory therapeutic approach…
Gadi Turgeman
Funding requested
$275,000
$275,000
Early Stage
Probing DNA Quadruplexes in Age Related Proteostasis
Ageing
Our research will aim to establish the role of DNA Helicases (WRN and BLM) as positive regulators of proteostasis and understand their impact of declining function prior to the onset of age-related proteostasis. Furthermore, the project will aim to develop genetic and pharmacolog…
Marco Di Antonio
Funding requested
$50,000
$50,000
Preclinical
Screening for antibodies that modulate the risk for Alzheimer’s disease
Ageing
Neuroscience/Neurology
We screen blood and saliva of elderly (90+) nondemented individuals to identify antibodies that protected them from developing Alzheimer’s disease. The data generated will be used (i) for predicting Alzheimer’s disease risk in individuals (ii) for new Alzheimer’s disease therapeu…
Daniel Z. Bar
Funding requested
$250,000
$250,000
Early Stage
Cellular ‘Soap’ For Infectious Disease Accelerated Aging
Ageing
Infectious Disease/Vaccines
Prevention of communicable disease via hygiene, antibiotics, vaccines, amongst other innovations has provided the largest life expectancy gains in human history. It is increasingly appreciated that pathogens age humans by driving their cell senescence. Our team has identified che…
Tim R. Peterson
Funding requested
$231,000
$231,000
Early Stage
ApoptoSENS - Senolytic CAR-NK cells
Ageing
Over time, a subset of cells in our body experience damage and enter a state of senescence. Cellular senescence is the irreversible arrest of proliferation accompanied by proinflammatory factors that lead to tissue dysfunction. Selective elimination of these senescent cells has b…
Amit Sharma
Funding requested
$430,000
$430,000
Preclinical
Towards reversing periodontal disease using Geroscience
Ageing
Oral Health
Periodontal disease (periodontitis) is a chronic oral disease impacting over 70% of older adults, where inflammation of the tissues supporting the teeth results in loss of connective tissue attachment, bone, and ultimately the tooth. The greatest underlying risk factor for period…
Jonathan An
Funding requested
$380,000
$380,000