Discover Research Projects

Dr. Joshua Johnson's research project focuses on the Integrated Stress Response (ISR) pathway, a pivotal molecular system that might help with the regulation of ovarian aging.

Soil microbes are key for nutrient cycling and plant health. Farming can disrupt these networks. Our project models and manipulates these ecosystems in a biosphere to understand these systems better, improve agriculture and support space habitation.

Soil microbes are key for nutrient cycling and plant health. Farming can disrupt these networks. Our project models and manipulates these ecosystems in a biosphere to understand these systems better, improve agriculture and support space habitation.

Soil microbes are key for nutrient cycling and plant health. Farming can disrupt these networks. Our project models and manipulates these ecosystems in a biosphere to understand these systems better, improve agriculture and support space habitation.

The project aims to investigate the role of the cGAS-STING pathway and cellular senescence in ovarian aging, with a focus on developing treatments to prevent ovarian reserve loss.

Our goal is to define damage-associated molecules released from tissues within the joint following exercise and determine how they are altered with aging, such that we can prevent injury and promote healing as we get older.

EDS patients may find that other extraterrestrial gravities are suitable. This can facilitate the study of Space-related pathophysiology. NOTE: I don't want to do this research. This is only a monetized suggestion.

Age-related diseases pose a pressing global health challenge, affecting a significant and growing portion of the population. The urgency to find effective solutions is paramount, given the current and projected future impact on individuals worldwide.

to inhibit pyruvate transport within mitochondria to target chemoresistance in PDAC

Xipiro developed a molecule, pNaKtide, that acts on a Master Control Switch to halt the generation of ROS. pNaKtide can be capitalized across a series of indications. With initial focus on ROP, Xipiro is raising to fully fund IND-enabling studies.

It is supposed to restore the structures of the joint, cartilage and meniscus by attracting their own synovial membrane stem cells using chemotaxis factors that will be produced by cartilage cells after the factor gene is delivered there by a vector

Drug discovery and development platform using peptoids to block viral transmission. Proof of concept for COVID-19 with two novel peptoids that block the interaction of SARS COV 2 and ACE2 receptor in live mammals. www.majorislife.com

The article will be translated from English to Tranditional Chinese: https://www.molecule.to/blog/the-scientific-singularity-our-vision-for-the-future-of-research-with-ip-nfts It will be published to Chinese communities as educaitonal purpose.

mushroom cultivation and therapy. Our mission is to combine technology and psychedelics to develop advanced solutions for growing and cultivating desired properties in psilocybin mushrooms

Combinatorial treatment of three compounds restored functions and proliferation of replicatively old cells within 3 days. An increase in RLS (50-100%) has been achieved. The combination may extend the chronological lifespan as well.

Combinatorial treatment of three compounds restored functions and proliferation of replicatively old cells within 3 days. An increase in RLS (50-100%) has been achieved. Like rapamycin, the combination may extend the chronological lifespan as well.

Latin for “Old Earth”, we patented a therapeutic suspension of Honey + Cannabis + Psilocybe.cubensis mushrooms. We are D&B registered, and currently providing access to 4 licensed counselors, and patients from 48 states.

I tried a combination therapeutic that resolved my long COVID symptoms and reversed biomarkers of cellular dysfunction.

Investigate clinically important genotypes and phenotypes of PCOS with distinct differences observed in women of different ethnicities. Using a big data approach in a multi-ethnic cohort to unravel the complex molecular mechanisms governing PCOS.

The study tests whether FDA-approved, topically-applied T3 and T4 promote the production of key growth factors, metabolism, and stem cell activities on human scalp skin to treat androgenic alopecia.

Lipids have a many applications, such as in foods, cosmetics & fuels. Oleaginous yeasts can produce high amounts of lipids and can be engineered using synbio. Here, we propose the development of novel methods to produce lipids at increased capacity.

The hypothesis is that a combination of exercise and periods of inactivity will result in better muscle performance in older adults than exercise alone.

2nd part of 5-MEO-DMT Study with IC & MU, our preliminary findings suggest that 5 may have similar anti-cancer properties as found in Aya, 16 candidates over 2 weekends in NL, First part youtube.com/playlist?list=PLHSn2eUQ0AF6wO3B5IA_g_vnN3Z4DSCJV

We seek to de-risk humanized anti-TIGIT antibodies through in vivo studies with Biocytogen’s transgenic mouse lines. It would be of tremendous interest to further de-risk these antibodies to unlock their values.

The study tests ex vivo—directly in the in the human target organ: scalp skin— whether FDA-approved, topically-applied T3 and T4 promote the production of key growth factors, metabolism, and stem cell activities required for human hair regrowth.

Permanently erases all painful, traumatic memories stored in the unconscious mind… as if the events had never happened. No clinical trials required. Safe and effective for PTSD. 100% natural. Results within 10-21 days. TraumaEraser.com

Rapid effect Low recurrence rate Non toxicity

A functionally biosimilar mRNA prophylactic or therapeutic vaccine, or vaccine booster, to enable sustained immunity to current and future SARS-CoV-2 variants.

Therapeutic viral vectors are common tools for gene delivery in research and clinical cell and gene therapy applications. These vectors have been widely used due to their efficiency in invading cells and introducing their genetic material. LUXTURNA (from Spark Therapeutics, Inc.)…

"You are what you eat" - food affects cognitive abilities of different social circles, potentially having major effect on or triggering conflicts between countries, classes and indigenous versus immigrant people. The research is going to verify effect by continuous testing of bas…

In order to properly protect LifeScienceData in the IP legal sense, we are exploring an appropriate new IP legal system which should harmonize IP system for the globe and existing IP legal system.

Through Cure-Hub's independent COVID-19 antibody survey, I collected a few hundred serum samples. These were tested for neutralizing antibodies against the SARS-CoV-2 receptor binding domain (RBD). The RBD is important because it is responsible for viral binding to human cells, a…

We have discovered that certain species of fungi produce psilocybin without having any gene homology with the genes that are known to be necessary and sufficient for psilocybin production. This indicates an undiscovered, non-canonical pathway for psilocybin production that we int…

Ageing weakens autophagy, affecting cell functions and causing diseases. Boosting autophagy might be a key to counter age-related health issues.

The global elderly population is projected to substantially increase throughout the 21st century. By the year 2100 a fifth of the total world population will be aged 65 or older posing a serious socioeconomic challenge to societies world-wide.

Dr. Daniel LaBarbera, with a team at the University of Colorado, has identified that TCF-transcription functions as a master regulator of EMT, and has discovered a novel factor within the TCF-transcription complex, CDH1L, as an inhibitor target, reversing EMT in CRC both in vitro…

Researchers at the University of Hawai‘i John A. Burns School of Medicine have developed novel antibody-oligonucleotide conjugates (AOCs) and a method for acquiring them. Incorporating activated esters (e.g., N-hydroxysuccinimidyl esters) into DNA or RNA aptamer libraries enables…

Novel pharmaceutical composition (LIPO-V) is a modulator of WNT signaling induces for repair and regeneration of intestinal epithelium. LIPO-V protects/mitigates RIGS following acute gastrointestinal (GI) radiation exposure.

Dr. Kennedy has developed a novel class of HMGA-1 inhibitors that can be used potentially in combination with existing chemotherapy agents for certain types of cancer.

Inventors at the University of Missouri have developed stable metal-seamed nanocapsules with unprecedented stoichiometry, shape, and size, such that the internal volume is large and is completely isolated from the exterior of the capsule.

Inventors at the University of New Hampshire have cloned GnRH-III and a type II GnRH Receptor from lamprey (an eel-like fish model organism).Lamprey GnRH-III stimulates release of FSH, but not LH, which makes it a useful tool for studying and developing novel GnRH analogs that ca…

AKT-mediated phosphorylation of CASTOR1 significantly increases its binding to RNF167, revealing a novel mTORC1 regulating mechanism and potential new therapeutic targets for mTORC1-dysregulated diseases.

Here we report series of small-molecule inhibitors of interactions between XPA and ERCC1 identified by high-throughput screening (HTS) of compound libraries.

Researchers at the University of Toledo have developed pancreatic beta-cell-specific chimeric antigen receptor (CAR) Tregs.

The inventors have designed and synthesized a novel inhibitor consisting of a glycopolymer of 12 repeating units bearing a pendant saccharide unit that allows this inhibitor to bind heparanase tighter than previously utilized agents.

Minicircle provides robust long-term, reversible expression of in vivo biologics without altering your preexisting genome. Minicircle is safe, ethical, accessible, and reversible gene therapy that can eradicate disease, reverse aging and transform public health.

At Biotein, we’re increasing the accessibility of proactive diagnostics for cellular health related to aging, using a lateral flow assay. It uses similar technology to pregnancy tests, costs 10-13% of current solutions, and detects proteins involved with almost all of the hallmar…

We have generated a unique database of human stem cell data and compare against cancer cells. Our platform identifies targets, e.g. for glioblastoma, confirming negligible expression in stem cells. We designed antisense oligonucleotides (ASOs) against these targets. All 6 drug ta…

Age-related diseases are in the top of 10 leading causes of global deaths killing 110K people daily. One of the main causes of such diseases like atherosclerosis, Parkinson's disease, Alzheimer's disease, neuromuscular, inflammatory and other age-related pathologies is intracellu…

The company intend to invest in a new pharmacological per-os treatment based on proprietary, patented glutathione derivative and polyphenols from Olea europaea. This pharmaceutical formulation is supported by a robust pre-clinical rationale and by preliminary clinical evidence of…

Cell reprogramming offers a path to comprehensive rejuvenation but has a goldilocks problem. Too little and you have no rejuvenation, too much and you risk cancer. To fulfil its potential (comprehensive reversal of biological age, avoidance/mitigation of age linked disease), cell…

We will leverage ML to design replacements for transcription factors implicated in longevity and cellular reprogramming. Numerous genes and transcription factors have been identified by other groups that can be used for cellular reprogramming or longevity extension (e.g. Yamanaka…

The primary aim of this proposal is a proof-of-concept experiment to mimic one of the most impressive genetic lifespan synergies in a model organism using human prescription drugs for which transcriptional signatures are available. The ultimate aim is to develop a more general te…

A big challenge facing tissue and organ replacement as a strategy to beat aging relates to the brain. The brain, especially the neocortex - the part that underlies our highest cognitive functions and self-identity - cannot obviously be replaced as a whole organ. The neocortex can…

First step of the A.I. for small molecule generation is to collect dataset that have SMILES of existing ligands. In order to train the model we should know proper protein structure to which small molecule binds. Then define its pocket 3D structure. This information is going to be…

Lactocore is an innovative start-up, developing novel drugs based on milk-derived peptides. The current pipeline consists of a number of preclinical and research compounds. The most advanced drug, LCGA-17, has shown very high efficacy in animal models of anxiety, depression, and …

Veloce BioPharma is clinical stage company that has successfully completed multiple phase 2 clinical trials in dermatology for indications that include molluscum contagiosum, chemotherapy associated paronychia, and common warts with our novel antiseptic formulation. As company fo…

Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration. Failure to clear cellular damaged mitochondria is majorly caused by compromised mitophagy. Turning up mitophagy via pharmaceutical approaches could improve brain health, healthspan, and…

Chronic inflammation increases with age and contributes to several age-related diseases. Current anti-inflammatory treatments have unintended side-effects ranging from slight discomfort to life-threatening ailments. We have developed a novel anti-inflammatory therapeutic approach…

Our research will aim to establish the role of DNA Helicases (WRN and BLM) as positive regulators of proteostasis and understand their impact of declining function prior to the onset of age-related proteostasis. Furthermore, the project will aim to develop genetic and pharmacolog…

We screen blood and saliva of elderly (90+) nondemented individuals to identify antibodies that protected them from developing Alzheimer’s disease. The data generated will be used (i) for predicting Alzheimer’s disease risk in individuals (ii) for new Alzheimer’s disease therapeu…

Prevention of communicable disease via hygiene, antibiotics, vaccines, amongst other innovations has provided the largest life expectancy gains in human history. It is increasingly appreciated that pathogens age humans by driving their cell senescence. Our team has identified che…

Over time, a subset of cells in our body experience damage and enter a state of senescence. Cellular senescence is the irreversible arrest of proliferation accompanied by proinflammatory factors that lead to tissue dysfunction. Selective elimination of these senescent cells has b…

Periodontal disease (periodontitis) is a chronic oral disease impacting over 70% of older adults, where inflammation of the tissues supporting the teeth results in loss of connective tissue attachment, bone, and ultimately the tooth. The greatest underlying risk factor for period…